PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .

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The pharmacodynamic activity and risk of hemorrhage with fibrinolytics pqckage increased if coadministered with defibrotide. Cathflo Activase should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Single-Use Vial Lytic Thrombolytic – Cathflo® Activase® (alteplase)

However, an increase in INR from 2. Moderate Due to the thrombocytopenic effects of vorinostat, an additive risk of bleeding may be seen in patients receiving concomitant thrombolytic agents. Invert the two vials so that the vial of alteplase is on the bottom and allow the entire amount of water to flow into the alteplase vials about 0. Cathflo Activase has not been studied in patients known to be at risk for bleeding events that may be associated with the use of thrombolytics.

We follow the manufacturer’s instructions of allowing a dwell time up to minutes checking periodically after 30 minutes for blood return. Use thrombolytic therapy with extreme caution in other conditions that can be exacerbated as a result of bleeding or in which bleeding could be hazardous or difficult to control due to its location.


Although we only use a total of 2 Alteplase doses in a 24hr time period. If the catheter is not functional after 30 minutes, allow the solution to remain for an additional 90 minutes minutes of total dwell time and assess catheter function by attempting to aspirate blood and catheter cahflo.

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Severe Aprotinin interferes with fibrinolysis by inhibiting the actions of kallikrein and plasmin, and it could inhibit fibrinolysis by thrombolytic agents. In another controlled study, patients who did not receive concomitant IV nitroglycerin reperfused pxckage, more often, and had fewer reocclusions.

The patient would then return to the Clinic for aspiration and flush. Alteplase has not been shown to adequately treat underlying deep vein thrombosis in patients with pulmonary embolism. Sodium Hyaluronate, Hyaluronic Acid: Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.

Bloomington St, Greencastle,IN In clinical trials, several episodes of bleeding were reported.

Major Based on the pharmacology of dabigatran, other oral anticoagulants and thrombolytic agents could cause additive risk of bleeding when given concurrently with dabigatran. Withdraw 1 mL into polypropylene syringes and cryopreserve at degrees C. If an arterial puncture is necessary, use an upper extremity vessel accessible to manual compression, apply pressure for at least 30 minutes, and monitor the puncture site closely for evidence of bleeding.


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Be sure to direct the stream of water into the lyophilized cake. Alteplase is not approved by the FDA to be prepared as cryopreserved bolus injections. Withdraw 2 mL 2 mg of solution from cathflk reconstituted vial. Hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of Cathflo Activase.

For subcutaneous ports, 0. Exercise caution in patients with active internal bleeding or other risk factors for bleeding within 48 hours of use. Prothrombin times stabilized during administration of both agents dathflo change slightly when heparin is discontinued. Do not use Bacteriostatic Water for Injection.

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Cathflo should be reconstituted immediately before use. There is significant variability in the management of pediatric stroke and practice standards for the use of thrombolysis have not been established.

Click “OK” if you are a healthcare professional. Patients receiving warfarin that catgflo concomitant icosapent ethyl therapy should have their Ihsert monitored more closely and the dose of warfarin adjusted accordingly. Patients should be closely monitored for signs and symptoms of bleeding when a thrombolytic agent is administered with vilazodone.

Within 3 hours of the onset of stroke symptoms. Push the vial down so that the piercing pin is inserted through the center of the vial stopper.