compared with a rate of 6–20% in cerebral malaria. Data on the prevalence of HMS is scant, but in areas with intense transmission of malaria. malarial splenomegaly. SIR—Hyper-reactive malarial splenomegaly (HMS) is a form of severe malaria, with a mortality rate that exceeds 50%,1,2 compared with . ABSTRACT. Hyper-reactive malarial splenomegaly (HMS) or Tropical splenomegaly syndrome(TSS), occurs in areas of high transmission of.

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Causes of massive tropical splenomegaly in Ghana.

Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients

Hyperreactive malarial splenomegaly in Europeans: Crane [ 2 ]. Hyperreactive malarial splenomegaly and tropical splenic lymphoma with villous lymphocytes. Data were extracted from all finally retained papers and specific fields of an Excel spreadsheet were populated.

Ethical approval of this study was obtained from the ethical committee at the Institute of Endemic Diseases, University of Khartoum. Reviews were excluded from the analysis.

Journal of Tropical Medicine

Published online Apr The spleen splenlmegaly generally firm and nontender with a prominent notch and regular contour. The funding body had no role in the study design, in the collection, analysis and interpretation of data, in the writing of the manuscript, and in the decision to submit the manuscript for publication. Spur cell anaemia and acute haemolysis in patients with hyperreactive malarious splenomegaly. The surgical risks of splenectomy are often considered to be unacceptable, which leaves these patients at splenpmegaly of bleeding and traumatic splenic rupture.


The mean spleen size was. A case of hyper-reactive malarial splenomegaly. On the basis of the full text, 51 papers were discarded since they did not deal with HMS. Measurement of total human IgM: Tropical splenomegaly syndrome in Nigerian adults. Thirty-nine patients were followed up for at least two weeks after treatment median six weeks showing improvement or a complete recovery.

Further testing showed a high antimalarial antibody titer and raised total IgM. Clearly, investigations of other possible causes of splenomegaly should be carried out, in particular, but not limited to, considering lymphoproliferative disorders. Bedu-Addo G, Bates I. The choice of drug may have been guided by the suggestion from the early s that chloroquine has an immunological effect on HMSS in addition to its antimalarial properties. English, French, Spanish, Italian, and Portuguese.

Hyper-reactive malarial splenomegaly in the absence of raised IgM antibodies. In the latter condition, too, a markedly raised anti-malarial antibody and IgM level have been observed [ 24 ]. J Am Board Fam Pract. However, using more sensitive diagnostic methods, such as polymerase chain reaction PCRthe proportion of positive cases increases [ 17 – 19 ].

Tropical splenomegaly syndrome – Wikipedia

Informed consent was obtained from all adults and in case of children from their parents or guardians. This particular aspect was described in a study showing a progressive enlargement of the liver after splenectomy in a patient with negative thick blood films.

Hyperreactive Malarial Splenomegaly HMS is characterized by massive enlargement of the spleen in the tropics.


Polymerase Chain Reaction PCR PCR analysis was carried out on samples collected from all patients for detection of malaria parasites; the primers specific for the polymorphic regions block 2 of merozoite surface protein 1 MSP1 and block 3 of Hyperreactiive were designed and described previously.

It was observed that some of those patients, if further exposed to malaria, evolved to the complete syndrome, and this suggested the possibility to splenmegaly the diagnosis at an early stage [ 43 ].

Tropical splenomegaly syndrome

No malaria parasites were detected in any of the HMS patients group using microscopic examination. Whether HMS is responsible for this high mortality is a fact that still needs to be established [ 6 ]. With available data the analysis was focused first on epidemiology, such as gender and age of patients, country where the study was conducted and country of origin of the patients, prevalence of the syndrome in a given area, mortality rate, etc.

By using this site, you agree to the Terms of Use and Privacy Policy. Hyperreactive malarial splenomegaly in Venezuela.

Experience in an isolated Yanomamo population of Venezuela. A cross-sectional study was carried out from January to December Van den Ende et al. Ann Trop Med Parasitol. Blood tests on presentation showed anemia, thrombocytopenia, and leucopenia.