JUPITER NEJM PDF

The results of the Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER; number. Editorial from The New England Journal of Medicine — JUPITER Clinical Directions — Polling Results. Authors & Reviewers · Submit a Manuscript · Subscribers · Institutions · Media · Advertisers · Agents · Permissions · Reprints · NEJM Career.

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They also raised concerns about conflict of interest in the trial design and leadership: Cardiovascular Quality and Outcomes.

Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

The article’s authors critiqued what they saw as flaws in the trial, pointing out that the cardiovascular mortality rate and the case-fatality rate for myocardial infarction were much lower than they expected. The trial focused on patients jkpiter normal low-density lipoprotein LDL cholesterol levels but increased levels of high-sensitivity C-reactive protein hs-CRP.

Comment in Ann Intern Med. The trial was stopped early, after just 1. An I ntervention T rial E valuating R osuvastatin trial was a clinical trial aimed at evaluating whether statins reduce heart attacks and strokes in people with normal cholesterol levels.

We randomly assigned 17, apparently healthy men and women with low-density lipoprotein LDL cholesterol levels of less than mg per deciliter 3. The trial was stopped after a median follow-up of 1.

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They concluded that, “The results of the trial do not support the use of statin treatment for primary prevention of cardiovascular diseases and raise troubling questions concerning the role of commercial sponsors.

Am J Kidney Dis. The trial analyzed 17, patients without evidence of heart disease but with high CRP levels. In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.

On the role of C-reactive protein, a study employing Mendelian randomizationpublished in the Journal of the American Medical Association suggested that CRP does not play a causal role in cardiovascular disease; the results may argue against CRP’s use as a marker of cardiovascular disease risk or for identifying subjects for statin therapy as in JUPITER, and more strongly argue against using CRP as a therapeutic target per se.

JUPITER trial – Wikipedia

The trial was sponsored by AstraZenecathe marketer of Crestor rosuvastatin. Consistent effects were observed in all subgroups evaluated. JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease. Because half of all vascular events occur in patients with normal or low levels of LDL cholesterol, JUPITER was designed to determine whether hs-CRP testing could identify these patients, and whether statin therapy could prevent cardiovascular events among them.

Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

Views Kupiter Edit View mejm. The rosuvastatin group did not have a significant increase in myopathy or cancer but did have a higher incidence of physician-reported diabetes.

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This page was last edited on 4 Novemberat Retrieved July 1, There were no significant differences between the treatment groups with respect to muscle pain, muscle weakness, hepatic function, or renal function; however, the researchers noted small but statistically significant increases in the rate of physician-reported diabetes and glycated hemoglobin values in the rosuvastatin group, an effect that has also been seen in studies with other statins.

Michel de Lorgeril, et al. From Wikipedia, the free encyclopedia.

Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, we hypothesized that people with elevated high-sensitivity C-reactive protein levels but without hyperlipidemia might benefit from statin treatment. Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular juputer. Inresults presented at the American Heart Association meeting and published in the New England Journal of Medicine found that patients with low-to-normal LDL cholesterol receiving rosuvastatin had a lower rate of major cardiovascular events.

N Engl J Med.

Retrieved from ” https: Clinical trials related to cardiology Clinical trials sponsored by AstraZeneca Statins. Jupjter rates of the primary end point were 0. Cleve Clin J Med. Compared to patients taking a placebopatients given rosuvastatin had reductions in LDL and CRP levels, and a reduction of 0. Results, Controversies, and Implications for Prevention”.